2020-21 Global Infectious Diseases Projects

The Global Infectious Diseases theme addresses the control of infection from a global perspective, exploiting our strengths in immunology, microbiology, diagnostics, clinical trials and global health and speaks directly to MRC strategic priorities in anti-microbial resistance (AMR) and vaccines as well as to the focus on epidemic preparedness.

Supervisors Project Key Words
Tihana Bicanic & Joseph Jarvis & Alan Pittman Identifying immunogenetic factors underlying susceptibility, severity and outcome of cryptococcal meningitis in African HIV-infected patients Cryptococcal meningitis
Genome-wide association study
Host-pathogen interaction
Genomics Immunophenotyping
Amaya Bustinduy & Michael Miles Development of molecular diagnostics for antihelmintic drug resistance monitoring in human schistosomiasis Schistosomiasis
Anthelmintic drug resistance
Comparative genomics
Quantitative epidemiology
David Conway & David Baker Adaptation and multiplication rate variation in the human malaria parasite Plasmodium falciparum Malaria
Transcriptome
Genome
Virulence
Populations
Disease
Phil Cooper & Irina Chis Ster Children growth impairment and markers of environmental enteropathy Environmental enteropathy
Growth impairment
Jonathan Friedland & Sandra Mounier-Jack & Sally Hargreaves The role of migrants in outbreaks of vaccine-preventable diseases in the UK and Europe Immunisation
Migrants
Outbreaks
Vaccination
Sebastian Funk & Flavio Finger & Nicholas Thomson Modelling optimal vaccination strategies for cholera outbreaks Cholera
Mathematical modelling
Outbreak response vaccination
Bioinformatics
Phylodynamics
Kai Hilpert & Debbie Baines Using Genomics and Peptidomics to Identify and Optimize Antibiofilm Peptides against Multi-drug Resistant Bacteria Multi-drug resistant bacteria
Biofilm
Antimicrobial peptide
Peptidomics,
Genomics
Screening
Rein Houben & Helen McDonald & Ian Douglas Linking acute and chronic cough to undetected transmission of Mycobacterium tuberculosis – analysis of UK electronic health records and mathematical modelling Tuberculosis
Mtb transmission
Respiratory tract infections
Electronic health records
Mathematical modelling
Adam Kucharski & Rachel Lowe & Sebastian Funk Combining novel data streams to forecast acute febrile illness in the Dominican Republic Forecasting
Dengue
Influenza
Surveillance
Modelling
Anna Last & Sanjeev Krishna & Taane Clark Genomic epidemiology of Plasmodium falciparum in the context of mass drug administration for malaria control on the Bijagos Archipelago of Guinea Bissau Malaria
Transmission
Genomics
Epidemiology
Cluster randomised control trials
Michael Lewis & John Kelly Investigating a gut-heart axis in the pathogenesis of Chagas cardiomyopathy Infection
Pathogenesis
Parasites
Genetics
Imaging
Sequencing
Jodi Lindsay & Gwenan Knight Identification and characterisation of barriers to antimicrobial resistance gene transfer Antimicrobial resistance
Bacteria
Genetics
Evolution
David MacLeod & Rashida Ferrand & Andrea Low Barriers to testing and treatment for adolescents and young people in sub-Saharan Africa HIV epidemiology
Adolescents
Maternal education
Statistical analysis
Nicky McCreesh & Tom Sumner Modelling the impact of inter-community transmission on reductions in tuberculosis incidence achieved through case finding interventions Tuberculosis
Social contact
Mathematical modelling
South Africa
Christopher Finn McQuaid & Matthew Quaife & Richard White Impact and cost-effectiveness of adherence technologies for drug-resistant tuberculosis treatment Tuberculosis
Drug-resistance Modelling
Health Economics
Robert Moon & Susana Campino High throughput approaches to strain-transcending malaria vaccine candidate selection Genome-editing
CRISPR-Cas9
Malaria
Vaccine
Serge Mostowy & Daniel Osborn & Alan Pittman Use of zebrafish to investigate the role of septins in host defence against Shigella infection Autophagy Cytoskeleton
Next generation sequencing
Shigella
Zebrafish
Kalpana Sabapathy & Virginia Anne Bond & Richard Hayes The role of alcohol in universal testing and treatment to reduce HIV incidence HIV/AIDS
Africa
Universal test and treat
Treatment as prevention
Alcohol
Cluster randomised trial
Blair Strang & Martin Goodier & Stuart Neil The role of ZAP in defence against human cytomegalovirus Cellular anti-viral factors
Virus
Cytomegalovirus
Tom Sumner & Richard White Exploring the effect of structural uncertainty in the mathematical modelling of tuberculosis Tuberculosis
Mathematical modelling Uncertainty
Jayne Sutherland & Hazel Dockrell & Taane Clark Identification of biomarkers for TB treatment response and lung function outcome: a longitudinal, multi-site, cohort study Tuberculosis
Human
Immunology
Lung pathology
Treatment response
Matthew Yeo & Ailie Robinson & Tom Walker A platform for the transgenic modification of Musca sorbens, the vector of trachoma, towards deriving insect vectors refractory to disease agent (Chlamydia trachomatis) mediated by CRISPR-Cas9 gene drive Trachoma
Musca sorbens
CRISPR-Cas9
Gene drives

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