2020-21 Quantitative Skills for Large Data Sets Projects

The Quantitative Skills for Large Data Sets theme addresses the MRC skill priority in quantitative skills and the MRC strategic research aims of investigating health through the life course, and how lifestyles and environment affect health.

Supervisors Project Key Words
Kaja Abbas & Mark Jit Health and economic impact modelling of cervical cancer elimination strategies at the global and national levels Human papillomavirus vaccine
Cervical cancer elimination
Infectious disease modelling
Cost-effectiveness analysis
Tom Barrick & Franklyn Howe & Rebecca Charlton Predicting Alzheimer’s disease and vascular dementia using novel neuroimaging biomarkers Alzheimer’s disease
Artificial intelligence
Machine learning
Neuroimaging
Magnetic resonance imaging
Diffusion imaging
Bridget Bax & Yalda Jamshidi Defining disease mechanisms and treatment responses in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) by multi-omics profiling and bioinformatical analysis Metabolomics
Bioinformatics
Clinical trial
miRNA
MNGIE
Krishnan Bhaskaran & Elizabeth Williamson Matched cohort methods in the analysis of e-Health data Epidemiology
Statistics
Pharmacoepidemiology methods
Tihana Bicanic & Joseph Jarvis & Alan Pittman Identifying immunogenetic factors underlying susceptibility, severity and outcome of cryptococcal meningitis in African HIV-infected patients Cryptococcal meningitis
Genome-wide association study
Host-pathogen interaction
Genomics
Immunophenotyping
John Bradley & Peter Smith Bayesian estimation of the aetiology of fever using big case-control data Statistics
Methodology
Bayesian
Aetiology
Fever
Big data
Elizabeth Brickley & Enny Paixao Cruz & Liam Smeeth The association of prematurity with paediatric hospitalizations and deaths in Brazil (2001-2015): A population-based linkage study Preterm Births
Hospitalization
Mortality
Epidemiology
Big Data
Brazil
Amaya Bustinduy & Michael Miles Development of molecular diagnostics for antihelmintic drug resistance monitoring in human schistosomiasis Schistosomiasis
Anthelmintic drug resistance
Comparative genomics
Quantitative epidemiology
Christopher Carroll & Shamima Rahman & Kate Everett Utilizing whole genome sequencing to revolutionize diagnosis of neurological disorders Whole genome sequencing
Neurological disease
Genomics
Diagnostics
Omics
Genome editing
David Conway & David Baker Adaptation and multiplication rate variation in the human malaria parasite Plasmodium falciparum Malaria
Transcriptome
Genome
Virulence
Populations
Disease
Phil Cooper & Irina Chis Ster Children growth impairment and markers of environmental enteropathy Environmental enteropathy
Growth impairment
Sue Cotterill & Axel Nohturfft How does the Df31 protein function to maintain chromatin structure and gene expression patterns Chromatin structure
Histone modifications
RNAseq
ChIPseq
RIPseq
HiC
Bioinformatics
Thomas Cowling & Joanna Davies & Jan van der Meulen Quantitative methods for analysing national electronic records for cancer patients in England: analysis of use of unplanned hospital care near the end-of-life Clinical epidemiology
Health services research
Medical statistics
End-of-life care
Cancer
Quantitative analysis
Karla Diaz-Ordaz & Stijn Vansteelandt Double machine learning methods for estimating causal treatment effects on cancer survival outcomes in the presence of high-dimensional confounding Causal inference
Machine learning
Targeted learning
Genomics
High-dimensional modelling
Rosalind Eggo & Antonio Gasparrini Viruses, pollution and chronic disease: modern data scientific techniques to address drivers of disease at multiple scales Data science
Modelling
Big data
Electronic health records
Infectious disease
Air pollution
Sebastian Funk & Flavio Finger & Nicholas Thomson Modelling optimal vaccination strategies for cholera outbreaks Cholera
Mathematical modelling
Outbreak response vaccination
Bioinformatics
Phylodynamics
Peter Garrard & Thomas Richard Barrick Understanding dimensionality in aphasic discourse Dementia
Discourse
Linguistics
Natural language processing
Machine learning
Deep learning
Antonio Gasparrini & Richard Atkinson & Ana Maria Vicedo-Cabrera Epidemiological studies on environmental risk factors using big data methods Big data
Regression modelling
Computing
Air pollution
Climate change
Rein Houben & Helen McDonald & Ian Douglas Linking acute and chronic cough to undetected transmission of Mycobacterium tuberculosis – analysis of UK electronic health records and mathematical modelling Tuberculosis
Mtb transmission
Respiratory tract infections
Electronic health records
Mathematical modelling
Yalda Jamshidi & Laura Southgate Tackling rare neuromuscular diseases Rare disease
Neuromuscular
Zebrafish
Genetics
Nicholas Jewell & Clémence Leyrat Methods for Addressing Immortal Time Bias: Application to Multiple Primary Melanomas Survival analysis
Melanoma
Multi-state models
Suneetha Kadiyala & Elizabeth Allen Application of causal mediation methods to examine the pathways to impact of an integrated agriculture-nutrition trial in India Nutrition
Agriculture
Participatory learning and action
Causal mediation analysis
India
Randomised controlled trial
Ruth Keogh & Linda Sharples & Elisa Allen Insights into liver transplantation and blood transfusion using registry data: statistical methods and applications Statistical methodology
Registry data
Organ transplantation
Blood transfusion
Observational data
Time-to-event analysis
Liver transplant
Sanjay Kinra & Iliatha Papachristou Nadal Evaluation of Complex Interventions for Management of Non-Communicable Diseases in Low-Middle Income Countries Process evaluation
Non-communicable disease
Disease management
Mixed methods
Global health
Petra Klepac & Adam Kucharski & Samuel Clifford Using large-scale data on human mobility and social behaviour to understand the transmission and control of respiratory infections in the UK Spatial epidemiology
Complex interventions
Human mobility
Social contacts
Adam Kurcharski & Rachel Lowe & Sebastian Funk Combining novel data streams to forecast acute febrile illness in the Dominican Republic Forecasting
Dengue
Influenza
Surveillance
Modelling
Anna Last & Sanjeev Krishna & Taane Clark Genomic epidemiology of Plasmodium falciparum in the context of mass drug administration for malaria control on the Bijagos Archipelago of Guinea Bissau Malaria
Transmission
Genomics
Epidemiology
Cluster randomised control trials
Alex Lewin & Sanjay Kinra Bayesian and probabilistic machine learning approaches for imputing and integrating spatiotemporal mobile phone location data Big data
Bayesian learning
Machine learning
Data integration
Clémence Leyrat & Aurélien Belot & Camille Maringe Measuring and quantifying clustering in population-based cancer survival analyses Clustering
Cancer research
Observational data
Survival analysis
Jodi Lindsay & Gwenan Knight Identification and characterisation of barriers to antimicrobial resistance gene transfer Antimicrobial resistance
Bacteria
Genetics
Evolution
David MacLeod & Rashida Ferrand & Andrea Low Barriers to testing and treatment for adolescents and young people in sub-Saharan Africa HIV epidemiology
Adolescents
Maternal education
Statistical analysis
Nicky McCreesh & Tom Sumner Modelling the impact of inter-community transmission on reductions in tuberculosis incidence achieved through case finding interventions Tuberculosis
Social contact
Mathematical modelling
South Africa
Joan Morris & Stephen James Weston Evans & Iain Carey Using data from EUROmediCAT to develop statistical methods to Identify medications that might harm the fetus if taken during the first trimester of pregnancy Medications
Pregnancy
Multiple comparison procedures
Jennifer Nicholas & Jonathan Rohrer & Chris Frost Design of clinical trials in genetic frontotemporal dementia Trial design
Neurology
Multivariate analysis
Longitudinal analysis
Statistics
Dorothea Nitsch & Alex Lewin Bayesian and probabilistic machine learning models for predicting sub-clinical and clinical morbidity in electronic health record data Big data
Bayesian learning
Machine learning
Data integration
Neil Pearce & Lucy Pembrey & Simon Kemp The long-term effects of playing rugby union on the cognitive function, brain health, psychological health, cardiovascular health and musculoskeletal health of former elite rugby union players Sport
Rugby
Health
Concussion
Lucy Pembrey & Karin van Veldhoven The role of the microbiome and epigenetics in asthma phenotypes and asthma control Big data
Biomarkers
Asthma
Big data
Biomarkers
Asthma
Lucy Platt & Rob Aldridge Evaluating peer advocacy interventions for people experiencing homelessness on attendance at health services Homelessness
Peer advocacy
Hospital episode statistics
Epidemiology
Ian Roberts & Asma Khalil & Haleema Shakur-Still Tranexamic acid for women with antepartum bleeding Antepartum haemorrhage
Tranexamic acid
Pregnancy outcomes
Stillbirth
Preterm birth
Randomised controlled trial
Alicja Rudnicka & Chris Frost & Christopher Owen Retinal vessel size and shape associations with brain structure and function Retinal vasculometry
Brain features
Neurodegenerative markers
Kalpana Sabapathy & Virginia Anne Bond & Richard Hayes The role of alcohol in universal testing and treatment to reduce HIV incidence HIV/AIDS
Africa
Universal test and treat
Treatment as prevention
Alcohol
Cluster randomised trial
Jayne Sutherland & Hazel Dockrell & Taane Clark Identification of biomarkers for TB treatment response and lung function outcome: a longitudinal, multi-site, cohort study Tuberculosis
Human
Immunology
Lung pathology
Treatment response
Stijn Vansteelandt & Ruth Keogh Use and development of statistical mediation techniques to understand the survival gap between males and females with cystic fibrosis Statistical methodology
Big data
Mediation analysis
Observational data
Time-to-event analysis
Cystic fibrosis
Elizabeth Williamson & Ian Douglas Improving statistical and machine learning methods for High Dimensional Disease Risk Scoring Statistical methodology
Biostatistics
Pharmacoepidemiology
Machine learning
High dimensional confounding
Angel Wong & Ian Douglas How can we optimise and advance the use of negative controls in observational study designs? Electronic health records
Negative control
Pharmacoepidemiology
Cardiovascular safety
Proton pump inhibitors Macrolides

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